Dr Sergio Lavandero is a very well-established scientist in Chile, who has achieved both national and international recognition. Currently, he is Full Professor with positions in two academic units (Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine) of the University of Chile. Also Dr Lavandero holds a Visiting Professor position in the Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center (Dallas, Texas, USA) for the period 2011-2015. Dr Lavandero is author of 182 publications in ISI journals (total citation: 6,207, h index 35). In the last 5 years (2008-2014) he published 101 papers, 15 of them in top 10 journals and a total of 5,099 citations.
His research has been supported by more than 24 FONDECYT grants (7 as principal investigator and 17 as co-investigator), 6 as principal investigator in international collaborative grants (ECOS-CONICYT, NIH-CONICYT, Redes, Spanish Education Minister). He was principal investigator of the Center for Molecular Studies of the Cell (CEMC) supported by the FONDAP grant 1501006 in the period 2002-2012. He is currently principal investigator in the Ring project in Science and Technology ACT 1111 (2012-2015) and Director of the new FONDAP Advanced Center for Chronic Diseases (2013-2023).
Dr Lavandero is member of the editorial boards of Am J Physiol (Endocrinology & Metabolism section), Cell Death & Diseases, Biochimica et Biophysica Acta- Molecular Basis of Disease; Biological Research, ISRN Cardiology, and Physiology Journal, Ad hoc reviewer in 32 international journals such as Circulation Research, Circulation, Journal of Biological Chemistry, Science Signaling, Diabetes, Hypertension, Cardiovascular Research, Nature Medicine and Journal of the American College of Cardiology. He serves as grant reviewer for CONICYT (Chile), CONICET (Argentina), Netherlands Organization for Scientific Research, Research Foundation Flanders & Barth Syndrome Foundation (USA), Israel Science Foundation, Latvian Science Council, Swiss National Science Foundation, CSIC Uruguay, and Belgian National Fund for Scientific Research (FNRS).
Dr Lavandero has held more than 33 lectures in scientific institutions abroad, in countries including Argentina, Brazil, Uruguay, Spain, Canada, U.S.A., U.K., Turkey and China. He is active member in national and international scientific societies (i.e. American Society for Biochemistry & Molecular Biology, International Cell Death Society, International Society for Heart Research, etc). He is currently President of the Chilean Society of Biochemistry & Molecular Biology (2013-2014). Over the course of the last 24 years, he has trained 66 undergraduate, 7 masters and 61 PhD students as well as 12 post-doctoral fellows.
Some of his most important administrative achievements include having served as president and representative member for Biology in the Higher Council of Science in FONDECYT (2003-2004) as well as Vice President of Research and Development (2013- to May 2014) and member of the Evaluation Council (2008-2012) of the University of Chile. Previously, Dr Lavandero was Director of Research (1998-2002) and Director of the Graduate School (2002-2006) at the Faculty of Chemical & Pharmaceutical Sciences.
1985 Pharmaceutical Chemist. University of Chile, Santiago, Chile
1993 Ph.D in Biochemistry. University of Chile, Santiago, Chile
1995 Postdoctoral Fellow; Lab of Dr. Derek LeRoith, NIDDK, NIH, Bethesda, MD, USA.
1996 Postdoctoral Fellow; Lab of Dr. Peter Sugden, National Heart & Lung Institute, Imperial College
Department Biochemistry & Molecular Biology, Faculty Chemical & Pharmaceutical Sciences, University of Chile:
Assistant Professor (1994-1999);
Associate Professor (1999-2005);
Program in Cell & Molecular Biology Faculty of Medicine, University of Chile:
Department of Internal Medicine, UTSW Medical Center, Dallas, Texas:
Visiting Professor (2010-)
Research Grants (as Principal Investigator, last 5 years)
2002 - 2012 FONDAP Chile Grant 15010006 (to Hidalgo C, Quest A, Jaimovich E, Lavandero S, Stutzin A, Devoto L, Hetz C, Michea L): "Center for Molecular Studies of the Cell (CEMC)"
2007 - 2011 FONDECYT Chile Project 1080436 (to Lavandero S): "Insulin resistance in type II diabetes: a study of new pathophysiological mechanisms associated with deterioration in cardiac function"
2012 - 2016 FONDECYT Chile Project 1120212 (to Lavandero S): "Regulation of mitochondrial dynamics and bioenergetics by insulin in cardiomyocytes"
2012 - 2015 ANILLO Grant ACT 1111 (to Lavandero S): "Metabolic stress signaling in non communicable diseases"
2013 - 2013 FONDAP Grant 15130011 (to Lavandero S, Quest AF, Ferreccio K, Kogan M, Castro E, Corvalan A): "Advanced Center for Chronic Diseases (ACCDiS)". Director: Lavandero S
Additional projects: 10, omitted here for space optimization
Since 2008 over 120 poster presentations at national (97) and international (23) meetings (omitted here for space optimization)
Ad-Hoc Reviewer for Journals
Reviewer for 32 journals such as: Am J Cardiol, Am J Physiol, Apoptosis, Cardiovasc Res, Circulation, Circulation Research, Endocrinology, FEBS Letters, Hypertension, J Biol Chem, Science Signaling, Cell Death Differ, Cell Death Dis, JACC, Nature Medicine, etc.
Grant reviewer for CONICYT (Chile), CONICET (Argentina), Netherlands Organisation for Scientific Research, Research Foundation Flanders & Barth Syndrome Foundation (USA).
Organization of International Meetings
Two symposia abroad (Cell Signaling Death International Meeting, Brazil; Cell Signaling Network, 2011, Mexico) and one in Chile.
Lectures at External Institutions
A total of 33 talks at different Universities abroad in Argentina, Spain, Canada, USA, Turkey, China, etc) and chilean Universities.
Human Resource TrainingPost-doctoral Fellows: 12
Muñoz JP, Troncoso R, Vicencio JM, Pedrozo Z, Contreras A, Parra V, Quiroga C, Pennanen C, Bustamante M, Mera C, Westermeier F, Valladares D.
PhD Students (as thesis advisor): 45
PhD in Biochemistry, University of Chile:
Moraga F, Navarro P, Criollo A, Marambio P, Troncoso R, Quiroga C, Díaz-Elizondo J, Contreras A, Parra V, Salas D, Rodríguez A, Bravo R, Garcia I, Paredes F, Crisosto C, Sotomayor C, Rivera P, Mendoza E.
PhD in Pharmacology, University of Chile:
Ortíz C, Egaña JT, Chiong M, Vicencio JM, Copaja M, Ibacache M, Galvis D, Valenzuela R, Aránguiz P, P Rojas, C Penannen, R Zepeda, R Vivar, Navarro M, Mondaca D.
PhD in Pharmaceutical Sciences, University of Chile:
Co-organizer with AQ and lecturer in 3 transversal post-graduate courses of the University of Chile:
Basic Concepts in Cell Signalling; Cell Signalling in Biomedicine; Advanced Cell and Molecular Biology.
Lecturer in other courses per year.
Participation in 12 Ph.D. thesis committees per year. Member of PhD programs in Biochemistry, Pharmacology, Biomedical Sciences, Molecular Cellular Biology and Neurosciences, Pharmaceutical Sciences, University of Chile.
Evaluation Council, University of Chile, member and academic secretary (2008- 2013).
Academic Qualification Higher Commission, University of Chile (2007-2008).
Vice-President of Research & Development, University of Chile (August 2012-May 2014).
Chilean Society of Biology; Chilean Society of Cell Biology; Chilean Society of Biochemistry; International Society for Heart Research, American Society for Biochemistry & Molecular Biology, International Cell Death Society, USA, European Cell Death Organization.
Editorial Boards and others
IUBMB Life (2011-2014), ISRN Cardiology (2011-), Biol Res (2010-), Am J Physiol (Endocrinol & Metab, 2009-), Cell Death & Diseases (2009-). International founding member of European Research Institute for Integrated Cellular Pathology (ERI-ICP, http://www.eri-icp.org, 2009-). Member of the Academy of Pharmaceutical Sciences, Chile (2011-). Chilean Society for Biochemistry & Molecular Biology: Vice-president (2011-2013), President (2013-2015).
Articles: Total: 216; last 5 years: 94.
Citations (Google Scholar): Total citations 12,243; last 5 years: 9,107
h-INDEX (Google Scholar): Total: 47, last 5 years: 41
Five Most Relevant Articles
1. Ibarra C, Vicencio JM, Estrada M, Lin Y, Rocco P, Rebellato P, Munoz JP, Garcia-Prieto J, Quest AFG, Chiong M, Davidson SM, Bulatovic I, Grinnemo KH, Larsson O, Szabadkai G, Uhlen P, Jaimovich E, Lavandero S. Local control of nuclear Ca2+ signalling in cardiac myocytes by perinuclear microdomains of sarcolemmal IGF-1 receptors. Circ Res 112: 236-245, 2013. ISI: 9.49 - Ranking 4/117.
2. Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy. J Clin Invest 122:1109-1118, 2012. ISI: 13.07 - Ranking 4/110.
3. Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early ER stress. J Cell Sci.124: 2143-2152, 2011. ISI: 6.11 - Ranking 39/179.
4. Vicencio JM, Ortiz C, Criollo A, Jones AWE, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M, Maiuri MC, Molgo J, Szabadkai G, Lavandero S#, Kroemer G#. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ 16:1006-17, 2009. #These authors share senior co-autorship. ISI: 8.85 - Ranking 23/289.
5. Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Insulin-like growth factor-1 rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. J Biol Chem 272:19115-19124, 1997. ISI: 4.77 - Ranking 66/287